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UVa Muscle Club is a volunteer-based interest group at University of Virginia with members in multiple disciplines across the grounds. We are concerned with all aspects of skeletal, cardiac and smooth muscles and diseases in which the muscles are involved. We hold regular meetings (once a month) on the second Wednesday.


Upcoming Meetings


New publications from UVa Muscle Club members in the recent months

Drake JC, Wilson RJ, Yan Z. Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle. FASEB J. 2015 Sep 14. pii: fj.15-276337. [Epub ahead of print] Review. PubMed PMID: 26370848.

Chao H, Li H, Grande R, Lira V, Yan Z, Harris TE, Li C. Involvement of mTOR in Type 2 CRF Receptor Inhibition of Insulin Signaling in Muscle Cells. Mol Endocrinol. 2015 Jun;29(6):831-41. doi: 10.1210/me.2014-1245. Epub 2015 Apr 15. PubMed PMID: 25875045; PubMed Central PMCID: PMC4447643.

Cohen TJ, Choi MC, Kapur M, Lira VA, Yan Z, Yao TP. HDAC4 regulates muscle fiber type-specific gene expression programs. Mol Cells. 2015 Apr;38(4):343-8. doi: 10.14348/molcells.2015.2278. Epub 2015 Feb 25. PubMed PMID: 25728750; PubMed Central PMCID: PMC4400309.

Call JA, Chain KH, Martin KS, Lira VA, Okutsu M, Zhang M, Yan Z. Enhanced skeletal muscle expression of extracellular superoxide dismutase mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling. Circ Heart Fail. 2015 Jan;8(1):188-97. doi: 10.1161/CIRCHEARTFAILURE.114.001540. Epub 2014 Dec 11. PubMed PMID: 25504759; PubMed Central PMCID: PMC4445759.

Lee HY, Gattu AK, Camporez JP, Kanda S, Guigni B, Kahn M, Zhang D, Galbo T, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Choi CS, Yan Z, Williams RS, Shulman GI, Samuel VT. Muscle-specific activation of Ca2+/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia. 2014 Apr 11. [Epub ahead of print] PubMed PMID: 24718953.

Laker RC, Xu P, Ryall KA, Sujkowski A, Kenwood BM, Chain KH, Zhang M, Royal MA, Hoehn KL, Dirscoll M, Adler PN, Wessells RJ, Saucerman JJ, Yan Z. A novel MitoTimer reporter gene for mitochondrial content, structure, stress and damage in vivo. J Biol Chem. 2014 Mar 18. [Epub ahead of print] PubMed PMID: 24644293.

Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. 2014 Apr;3(2):114-23.

Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, Turner N, James DE, Yan Z, Hoehn KL. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Mol Metab. 2014 Apr;3(2):124-34.

Okutsu M, Call JA, Lira VA, Zhang M, Donet JA, French BA, Martin KS, Peirce-Cottler SM, Rembold CM, Annex BH, Yan Z. Extracellular Superoxide Dismutase Ameliorates Skeletal Muscle Abnormalities, Cachexia and Exercise Intolerance in Mice with Congestive Heart Failure. Circ Heart Fail. 2014 Feb 12. PubMed PMID: 24523418

Meeting Information

ACSM Conference on Integrative Physiology of Exercise (IPE), Sept. 17-20, 2014
2nd Cancer Cachexia Conference: Evolving Mechanisms and Therapies, Montreal, Canada, September 26-28, 2014
16th International Conference on Biochemistry of Exercise, Sao Paulo, Brazil, September 7-9, 2015